DNA modification

The abnormal DNA modification is characteristically a hallmark of cancer cells .

不正常的DNA修饰是癌症细胞的典型特征。

There are many reasons that cause transgene inactivation , and inactivation can emerge at different gene expression stage , such as DNA modification level , transcriptional level and post-transcriptional level .

引起外源基因失活的原因是多方面的，外源基因失活在DNA修饰水平，基因转录水平和转录后调节水平均可能发生。

UCLA researchers also compared the neural stem cells they grew to cancer cells to ensure that the neural stem cells did not have any abnormalities in a DNA modification associated with gene silencing .

UCLA的研究人员同时也比较了他们的干细胞和癌症细胞的DNA以保证这些神经干细胞没有导致基因沉默的不正常的DNA修饰。

Combining with the work of our laboratory , we reviewed and discussed the advances of the mutational effects and their applications , mutational mechanisms and DNA modification on plants of low-energy ions here .

结合本实验室的工作，就低能离子对植物体的诱变效应及其应用、诱变机理和DNA修饰等方面的进展进行综述和讨论。

High blood glucose level determines overproduction of reactive oxygen species ( ROS ) while high reactivity of ROS determines chemical changes in virtually all cellular components , leading to DNA and protein modification and lipid per-oxidation .

高血糖导致活性氧簇（ROS）的过度表达，可使细胞内出现化学反应.从而导致DNA和蛋白质损伤修复以及脂质过氧化。

Comparison of Three Methods for Genomic DNA Extraction and the Modification of One of the Three Methods

三种全血提取基因组DNA方法的比较及Genomix方法的改良

The Effect of DNA Methylation and Histone Modification on the Development of Cloned Embryos

DNA甲基化与组蛋白修饰对克隆胚发育的影响

Objective DNA methylation and chromatin modification of histone acetylation are two global mechanisms that regulate gene expression .

目的DNA甲基化和组蛋白乙酰化是基因表达调控的主要形式。

Aberrant DNA Methylation and Histone Modification in Tumor

肿瘤DNA异常甲基化与组蛋白修饰

Many studies have explored the mosaic patterns of DNA methylation and histone modification in cancer cells on a gene-by-gene basis ;

很多研究已经在逐基因地基础上探寻了癌症细胞中DNA甲基化和组蛋白质修饰的镶嵌模式；

Epigenetics involves in the heritable but reversible regulation of various gene expression through DNA methylation and chromatin modification without sequence alternation .

表观遗传是研究没有DNA序列变化，但是可遗传和可逆转的基因组功能的调控。

The changes of epigenetics such as DNA methylation and histone modification can regulate the expression of genes and play an important role in the development of tumors .

表遗传学改变，如DNA甲基化和组蛋白修饰改变可以调节基因的表达，在肿瘤的发生和发展中可能起关键作用。

The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones .

植物基因组的功能依赖于染色质标记，诸如DNA的甲基化和组蛋白的转录后修饰。

Epigenetic mechanisms , including DNA methylation , histone modification and chromatin remodeling , have been demonstrated to be involved in the development of SLE .

表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。

Epigenetic variation plays an important role in plant growth and development , including DNA methylation , histone modification , chromosome remodeling , and RNA interference and so on .

表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。

Non-DNA sequence variations , such as DNA methylation and histone modification , can also change biological traits such as plant height , flowering time , resistance and yield .

非DNA序列变异，如DNA甲基化、组蛋白修饰等亦可改变生物性状，包括重要农艺性状如株高、花期、抗性、产量等，并可稳定遗传。

Core processes of epigenetic inheritance include DNA methylation , histone modification , nucleosome remodeling , nuclear dynamics and chromatin interaction with non-coding RNAs .

核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。

Two forms of DNA damage caused by peroxynitrite are DNA base modification and DNA single strand breakage .

过亚硝酸根对DNA的损伤主要有两种形式：DNA碱基修饰与DNA单链断裂。

DNA methylation is the only natural vertebrate DNA chemical modification , such as in the regulation of gene expression play an important role .

DNA甲基化是脊椎动物DNA唯一的自然化学修饰，在基因表达调控等方面发挥重要作用。

Based on those disadvantages of traditional methods , the study for DNA demethylation and the relationship between DNA methylation and histone modification are difficult .

因此，也就为研究DNA去甲基化以及DNA甲基化与组蛋白修饰之间的关系造成了麻烦。

Epigenetics refers to gene expression changes which DNA sequence will not changed , the main contents of epigenetic mechanism is that DNA methylation and histone modification .

表观遗传学指不发生DNA序列改变的基因表达改变，DNA甲基化和组蛋白修饰是其中的两个主要内容。